Xenotransplantation: Recently, the Chinese researchers successfully transplanted a genetically modified pig liver into a brain-dead human recipient to assess its survival and functionality.
o Ex Vivo Interaction: Includes human cells, tissues, or organs that have had prior contact with non-human animal cells/tissues outside the body.
o Historical Background: Early attempts at human heart xenotransplantation in the 1980s.
o Genetic Modifications: Essential to prevent immune rejection in human recipients.
o Post-Transplant Monitoring: Ensures organ functionality and detects potential immune responses.
o Medical Use: Pig heart valves have been used in human valve replacements for over 50 years.
o Similarity: Anatomical and physiological resemblance to humans makes pigs ideal donors.
o Availability: Pigs are widely farmed, making organs cost-effective and scalable.
o Size Matching: Variety of pig breeds allows organ size customization for human needs.
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