GENOME INDIA PROJECT (Syllabus: GS Paper 3 – Sci and Tech)

News-CRUX-10     28th February 2024        
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Context: The Department of Biotechnology (DBT) recently officially announced the completion of the '10,000 genome' project an endeavor aimed at establishing a reference database of whole-genome sequences originating from India.

Genome India Project

  • About: It is a gene mapping initiative authorized and funded by the Department of Biotechnology and led by the Indian Institute of Science's Centre for Brain Research.
  • Inspired from: Human Genome Project (HGP), an international effort that successfully decoded the entire human genome between 1990 and 2003.
  • Genetic Database: Launched to establish a thorough database of genetic variations within the Indian populace.
  • Aim: To sequence genomes of 10,000+ individuals across diverse regions to establish a reference genome.
  • Priority Areas of Investigation

oPrecision Health

oRare Genetic Disorders

oMutation Spectrum of Genetic Diseases

oGenetic Epidemiology of Lifestyle Diseases

oTranslational Research

  • Significance of the Genome India Project

oUnderstanding Unique Genetic Variants: Provides insight into genetic variants specific to India's population, enabling tailored drug and therapy development.

oUnraveling Genetic Underpinnings: Helps uncover genetic roots of prevalent chronic diseases like diabetes, hypertension, cardiovascular diseases, neurodegenerative disorders, and cancer.

oDatabase for Diverse Population: India's diverse population, comprising over 4,600 groups, harbors distinct genetic variations, necessitating a specific database.

oUniqueness of Indian Genetic Landscape.

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