Context: The Indian Council of Medical Research (ICMR) has invited Expressions of Interest (EoI) from eligible organisations for the “joint development and commercialisation” of low dose or paediatric oral formulation of hydroxyurea to treat sickle cell disease in India.
Sickle Cell Anaemia
oIt affects the shape of red blood cells, which carry oxygen to all parts of the body.
oIn sickle cell anaemia, some red blood cells are shaped like sickles or crescent moons.
oThese sickle cells also become rigid and sticky, which can slow or block blood flow.
oIn later stages, individuals may experience severe pain, anaemia, organ damage, and increased susceptibility to infections.
oHydroxyurea reduces pain frequency and prevents long-term complications; transplantation is an option too.
Indian Council of Medical Research (ICMR)
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