theIASHub | 18 Apr, 2025
De-extinction of Dire wolves: Colossal Biosciences, a biotechnology company in Texas, recently announced that it had “resurrected” a dire wolf, a large predator that went extinct more than 12,000 years ago.
o Similarity: Gray wolf and dire wolf (Aenocyon dirus) genomes are 99.94% identical, i.e., 2.445 billion base pairs are the same.
o Difference: The remaining 0.06% (or 1.47 million base pairs) makes the two animals genetically distinct.
o Comparison: Humans and chimpanzees share 98.77% DNA, yet are very different — highlighting that small genetic differences are significant.
o Colossal's approach: Scientists edited the gray wolf genome and implanted embryos into surrogate dog mothers.
o Genetic edits: Edits were made at 20 loci across 14 genes to “recreate” the dire wolf.
o Estimate: These edits likely represent only 0.02% of the total genetic differences, indicating the pups are not true dire wolves.
o LCORL gene: One of the edited genes is LCORL, linked to larger size in dire wolves.
o Result: Colossal Biosciences has created gray wolves that look like dire wolves, rather than true dire wolves.
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