theIASHub | 31 Jul, 2025 | 4
Study on Respiratory Infections : Recently published in Nature, a groundbreaking study has revealed that common respiratory infections like COVID-19 and influenza can awaken dormant breast cancer cells lodged in the lungs.
o Caused by uncontrolled growth of cancerous cells in the breast.
o About 80% of cases are invasive, meaning the cancer can spread to other parts of the body.
o This reactivation led to rapid development of aggressive metastatic tumors within days.
o Molecular Trigger: Interleukin-6 (IL-6), a pro-inflammatory molecule released during infections, was identified as the key driver of DCC reactivation.
ü Blocking IL-6 could potentially prevent metastasis following respiratory infections.
o Human Data Reinforces the Risk: Among cancer survivors (in remission ≥5 years), those infected with COVID-19 had nearly twice the risk of cancer-related death (excluding COVID fatalities).
ü Among 36,000+ breast cancer patients, those with COVID-19 were 50% more likely to develop lung metastases compared to uninfected peers.
o The study highlights the importance of vaccinations and continued medical follow-up for cancer survivors.
o The research deepens awareness of how post-viral effects extend beyond the acute illness.
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