AdFalciVax : Recently, the Indian Council of Medical Research (ICMR) invited domestic vaccine manufacturers to collaborate on the commercial rollout of its newly developed malaria vaccine, AdFalciVax.
o Dual Protein Targets: It expresses two key proteins of the malaria parasite, aiming for enhanced protection compared to current vaccines that target only parasite fragments.
o Full-Length CSP Gene: The vaccine includes the complete gene for the circumsporozoite protein (CSP), a major surface protein of Plasmodium falciparum, the deadliest malaria parasite. This is expected to generate a more robust and long-lasting immune response.
o Transmission Blocking Component: AdFalciVax also includes a second component aimed at disrupting the parasite's lifecycle within the mosquito, thereby reducing community-level transmission.
o The vaccine has been developed by the ICMR-Regional Medical Research Centre (RMRC), Bhubaneswar.
o Upcoming versions of AdFalciVax may aim to broaden protection to include other malaria-causing parasites such as P. vivax, P. malariae, P. ovale, and the zoonotic P. knowlesi.
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