TR1 cells

TR1 cells : Recently, a study published in Science Immunology revealed that Type-1 Regulatory T cells (TR1) play a dominant role in the immune response against the malaria parasite Plasmodium falciparum.

• About TR1 Cells: These cells dominate the malaria-specific CD4+ T-cell response, making up 90% of all malaria-specific helper T-cells, despite constituting only 3% of resting CD4+ cells.

o T cells: T cells are a type of white blood cell, also known as lymphocytes, that play a vital role in the immune system. They help immune system fight germs and protect you from disease. There are two main types.

- Cytotoxic T cells: Also called CD8+ cells because they have a CD8 receptor on their membranes. They destroy infected cells.

- Helper T cells: Also called CD4+ cells because they have a CD4 receptor on their membranes. Unlike cytotoxic T cells, helper T cells don’t kill cells directly. They send signals that direct other immune cells to fight infection.

o TR1 cells display strong clonal fidelity, meaning they maintain a consistent, specific response to the malaria parasite over time, exhibit long-lasting immunological memory.