GenTIGS

GenTIGS : Recently, the Tata Institute for Genetics and Society (TIGS), Bengaluru, developed GenTIGS, a gene database aimed at facilitating the early identification and diagnosis of rare genetic disorders.

• About GenTIGS : An integrated gene database that catalogs genes and pathogenic variants linked to rare genetic disorders (RGDs).

o It is designed to simplify access and analysis of data related to RGDs and their associated genetic mutations, such as: Nonsynonymous mutations, Microsatellites and Gene duplications

o Key Information Provided: Globally and Indian-prevalent rare genetic disorders

ü Causative genes and specific mutations

ü Descriptions of the disorders

ü Gene Ontology (GO) terms

ü Clinical interpretations and Cross-references to external genomic databases

o Features : Offers flexible search options and a user-friendly browser.

ü Includes hyperlinks to various external datasets for in-depth exploration.

ü Supports both experimental and computational research on rare disorders.

• Built using data from: Published scientific research

o Existing genomic databases

o The latest Human Genome sequence data

o Variants in GenTIGS are mapped to IndiGenomes metadata for accurate annotation and understanding of disease associations