NANO-MIND TECHNOLOGY (Syllabus: GS Paper 3 – Sci and Tech)
Context: Researchers from the Korean Institute of Basic Science have developed a new magnetogenetics technology called Nano Magnetogenetic Interface for NeuroDynamics (Nano-MIND), which has been successfully demonstrated in mice.
Nano-MIND Technology
- About: Nano-MIND (Magnetogenetic Interface for NeuroDynamics) technology enables advanced understanding and control of complex brain functions such as cognition, emotion, and motivation.
- Wireless and Precise Modulation: It allows for wireless, remote, and accurate modulation of specific deep brain neural circuits using magnetic fields.
- Innovative Activation Method: The technology utilizes magnetic fields and magnetized nanoparticles to selectively activate targeted brain circuits, marking a significant improvement over traditional brain manipulation methods.
- Highlights of the Research:
oNeuron Activation in Mice: The research team demonstrated Nano-MIND’s capabilities by activating specific neurons in various brain regions of mice.
oMaternal Behaviors Induction: A notable achievement was the activation of inhibitory GABA receptors in the medial preoptic area (MPOA), leading non-maternal female mice to exhibit increased nurturing behaviors.
oFeeding Behaviors Regulation: The team regulated feeding behaviors by targeting motivation circuits in the lateral hypothalamus, achieving a 100% increase in appetite with inhibitory neuron activation, and a more than 50% reduction with excitatory neuron activation.
- Significance of the Research: The research represents a major advancement in neuroscience and holds potential for developing brain-computer interfaces (BCIs) and treating neurological disorders.
